دانلود مقاله : 

Experimental design for gene expression microarrays 2001

نویسندگان : 

M. KATHLEEN KERR, GARY A. CHURCHILL

چکیده : 

We examine experimental design issues arising with gene expression microarray technology. Microarray

experiments have multiple sources of variation, and experimental plans should ensure that effects

of interest are not confounded with ancillary effects. A commonly used design is shown to violate this

principle and to be generally inefficient. We explore the connection between microarray designs and

classical block design and use a family of ANOVA models as a guide to choosing a design. We combine

principles of good design and A-optimality to give a general set of recommendations for design with

microarrays. These recommendations are illustrated in detail for one kind of experimental objective, where

we also give the results of a computer search for good designs

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