Joint modelling of longitudinal measurements and event time data
چهارشنبه , 20 شهریور 1392 ساعت 13:18 دسته بندی :دانلود مقاله :
Joint modelling of longitudinal measurements and event time data 2000
نویسندگان :
ROBIN HENDERSON , PETER DIGGLE, ANGELA DOBSON
چکیده :
This paper formulates a class of models for the joint behaviour of a sequence of longitudinal
measurements and an associated sequence of event times, including single-event survival data. This class
includes and extends a number of specific models which have been proposed recently, and, in the absence
of association, reduces to separate models for the measurements and events based, respectively, on a
normal linear model with correlated errors and a semi-parametric proportional hazards or intensity model
with frailty.
Special cases of the model class are discussed in detail and an estimation procedure which allows the
two components to be linked through a latent stochastic process is described. Methods are illustrated using
results from a clinical trial into the treatment of schizophrenia.
?> Biomarkers Counting processes Informative drop out Repeated measurements Serial correlation Survivalمطالب مرتبط :