Neural Antecedents of Emotional Disorders: A Functional Magnetic Resonance Imaging Study of Subsyndromal Emotional Symptoms in Adolescent Girls
پنجشنبه , 17 مرداد 1392 ساعت 23:58 دسته بندی : علم پزشکی ,دانلود مقاله :
Neural Antecedents of Emotional Disorders: A Functional Magnetic Resonance Imaging Study of Subsyndromal Emotional Symptoms in Adolescent Girls 2013
نویسندگان :
Pritha Das, Carissa M. Coulston, Danielle M. Bargh, Michelle Tanious, K. Luan Phan,Vince D. Calhoun, and Gin S. Malhi
چکیده :
Background: Emotional symptoms (ES) emerge forme fruste in adolescence, before manifesting as fully fledged emotional disorders.
Studies indicate that subsyndromal ES precede the onset of emotional disorders. We hypothesized that adolescents showing
subsyndromal ES will show perturbations in the emotion regulatory frontolimbic network (FLN) during emotion processing.
Methods: Fifty-eight female adolescents underwent functional magnetic resonance imaging while viewing an image-based emotionprocessing
task. Within this sample, 33 (56.9%) displayed emotional symptoms and 25 (43.1%) did not. Clinical measures, including
assessments of mood and anxiety, were administered and participants were allocated to one of two groups based on the presence
(ES) or absence (ES) of subsyndromal ES. Group comparisons were used to identify differential patterns of neural engagement and
their relationship to clinical variables.
Results: Groups displayed emotion-specific differences in FLN activity with increased frontal activity in ES girls during positive
emotion processing and decreased frontal and limbic activity during negative emotion processing. Trait anxiety was the strongest
clinical predictor of group membership (ES versus ES) and displayed a significant negative correlation with hippocampal neural
activity during negative emotion processing. In addition, between the groups, the hippocampus displayed a pattern of reverse coupling
with the amygdala and insula that was also significantly correlated with trait anxiety.
Conclusions: There is divergence in the pattern of FLN neural processing in adolescent female subjects determined by emotional
symptoms. Future research is needed to corroborate these findings and to underline their implications longitudinally.
?> Adolescents , anxiety , depression , emotional disorders , emotional network , fMRI , دانلود مقاله , دانلود مقاله پزشکی , سایت دانلود مقالهمطالب مرتبط :
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Neural Antecedents of Emotional Disorders: A Functional Magnetic Resonance Imaging Study of Subsyndromal Emotional Symptoms in Adolescent Girls
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