Protein tyrosine phosphatases as novel targets in breast cancer therapy
یکشنبه , 06 مرداد 1392 ساعت 03:18 دسته بندی : , علم پزشکیدانلود مقاله :
(2013)Protein tyrosine phosphatases as novel targets in breast cancer therapy
نویسندگان :
Caroline E. Nunes-Xavier , Jorge Martín-Pérez , Ari Elson , Rafael Pulido
چکیده :
Breast cancer is linked to hyperactivation of protein tyrosine kinases (PTKs), and recent studies have unveiled
that selective tyrosine dephosphorylation by protein tyrosine phosphatases (PTPs) of specific substrates,
including PTKs, may activate or inactivate oncogenic pathways in human breast cancer cell growth-related
processes. Here, we review the current knowledge on the involvement of PTPs in breast cancer, as major
regulators of breast cancer therapy-targeted PTKs, such as HER1/EGFR, HER2/Neu, and Src. The functional
interplay between PTKs and PTK-activating or -inactivating PTPs, and its implications in novel breast cancer
therapies based on targeting of specific PTPs, are discussed.
مطالب مرتبط :
Protein tyrosine phosphatases as novel targets in breast cancer therapy
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