دانلود مقاله : 

Signal-dependent Elk-1 target genes involved in transcript processing and cell migration 2013

نویسندگان : 

Aneta Kasza

چکیده : 

Elk-1 was regarded as a transcription factor engaged mainly in the regulation of cell growth, differentiation,

and survival. Recent findings show the engagement of Elk-1 in the control of expression of genes encoding

proteins involved in transcript turnover, such as MCPIP1/ZC3H12A and tristetraprolin (TTP/ZFP36). Thus,

Elk-1 plays an important role in the control of gene expression not only through the stimulation of expression

of transcription factors, but also through regulation of transcript half-live. Moreover, Elk-1 is engaged in the

regulation of expression of genes encoding proteins that control proteolytic activity, such as inhibitor of

plasminogen activator-1 (PAI-1) and metalloproteinases-2 and -9 (MMP-2 and MMP-9). This review summarizes

the biological roles of proteins with expression regulated by Elk-1, involved in transcripts turnover or in

cell migration. The broad range of function of these proteins illustrates the complex role of Elk-1 in the

regulation of cancer and inflammation.

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