Yellow fever vaccine: Comparison of the neurovirulence of new 17D-204 Stamaril
جمعه , 18 مرداد 1392 ساعت 00:58 دسته بندی : علم زندگی ,دانلود مقاله :
Yellow fever vaccine: Comparison of the neurovirulence of new 17D-204 Stamaril seed lots and RK 168-73 strain 2013
نویسندگان :
Jean-Claude Moulin , Jérémy Silvano , Véronique Barban , Patrice Riou , Caroline Allain
چکیده :
The neurovirulence of two new candidate 17D-204 Stamaril working seed lots and that of two reference
preparations were compared. The Stamaril working seed lots have been used for more than
twenty years for the manufacturing of vaccines of acceptable safety and efficacy. The preparation
designated RK 168-73 and provided by the Robert Koch Institute was used as a reference. It was
confirmed that RK 168-73 strain was not a good virus control in our study because it has a very low
neurovirulence regarding both the clinical and histopathological scores in comparison with Stamaril
strain and is not representative of a vaccine known to be satisfactory in use. The results were reinforced
by the phenotypic characterization by plaque assay demonstrating that RK 168-73 was very different
from the Stamaril vaccine, and by sequencing results showing 4 mutations between Stamaril and RK
168-73 viruses leading to amino acid differences in the NS4B and envelop proteins.
?> Yellow fever vaccine Seeds 17D 204 Stamaril RK 168 73 Vaccine characterization Neurovirulence , دانلود مقاله زیست شناسی , دی ان ایمطالب مرتبط :
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